RNAi_safe

Safety of RNAi technology in plant protection: Method evaluation for estimating effectivity and potential impacts on target and off-target organisms

Term

2022-01-01 bis 2026-02-15

Project management

• Torsten, Will
• Silvio, Erler

Responsible institute

Institut für Bienenschutz

Project preparer

• Khalid, Amari
• Antje, Dietz-Pfeilstetter
• Torsten, Will
• Christoph, Joachim
• Silvio, Erler

Cooperation partner

• Institut für Phytomedizin
• Institut für Pflanzenschutz in Ackerbau und Grünland (JKI)
• Institut für die Sicherheit biotechnologischer Verfahren bei Pflanzen (JKI)
• Institut für Resistenzforschung und Stresstoleranz (JKI)

Overall objective of the project

“RNAi_safe” pursues a methodological approach to answer open questions about the safe use of RNAi technology in plant protection. The project aims at detecting and evaluating of potential exposure pathways and effects of dsRNA-based plant protection products in target organisms (long-term effects), crops (secretion, depot formation) and the extended food web (off-target organisms). Further, it will help in developing expertise to evaluate methods for assessing plant protection products, using RNAi technology as a mode of action. Finally, existing methods for assessing dsRNA-based plant protection products in the risk assessment will be developed and evaluated.

Funder

Federal Ministry of Food and Agriculture